William Blake (1757-1827) produced books in a total act of self-publishing. He wrote the text, made relief etchings of the text (as mirror image) and the illustrations, printed and hand colored the pages.
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Look at an egyptian papyrus with text and image done by hand
Look at a 20th century Russian self-publication
Look at cave paintings (20,000 year old self-publishing)
Look at a contemporary American self-published artist book
Copyight 1996 Text by Richard Minsky, Blake images thanks to Steven Marx of The Blake Multimedia Project